Publication: Synthesis of Two Key Fragments of the Complex Polyhalogenated Marine Meroterpenoid Azamerone
Synthesis of Two Key Fragments of the Complex Polyhalogenated Marine Meroterpenoid Azamerone
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Schnell, S. D., Linden, A., & Gademann, K. (2019). Synthesis of Two Key Fragments of the Complex Polyhalogenated Marine Meroterpenoid Azamerone. Organic Letters, 21, 1144–1147. https://doi.org/10.1021/acs.orglett.9b00090
Abstract
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Abstract
A concise route toward two advanced fragments in the context of the total synthesis of the unique natural product azamerone is reported. Key synthetic features include the enantioselective synthesis of an epoxysilane and its Lewis-acid-induced cyclization and the installation of the pyridazine ring via a formylation/condensation sequence. This route provides strategic insights into the chemistry of phthalazinediols, facilitating synthetic approaches toward this class of natural products.
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- Schnell, Simon D
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Schnell, S. D., Linden, A., & Gademann, K. (2019). Synthesis of Two Key Fragments of the Complex Polyhalogenated Marine Meroterpenoid Azamerone. Organic Letters, 21, 1144–1147. https://doi.org/10.1021/acs.orglett.9b00090
