Publication: Innate Immunity to Adenovirus
Innate Immunity to Adenovirus
Date
Date
Date
Citations
Hendrickx, R., Stichling, N., Koelen, J., Kuryk, L., Lipiec, A., & Greber, U. F. (2014). Innate Immunity to Adenovirus. Human Gene Therapy, 25(4), 265–284. https://doi.org/10.1089/hum.2014.001
Abstract
Abstract
Abstract
Human adenoviruses are the most widely used vectors in gene medicine, with applications ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side effects. In addition, natural adenoviruses pose severe risks for immuno-compromised people, yet, infections are usually mild and self-limiting in immuno-competent individuals. Here we describe how adenoviruses are recognized by the host innate defense system during entry and replication in immune and non-immune cells. Innate defense protects the host, and
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Creators (Authors)
- Hendrickx, Rodinde
- Stichling, Nicole
- Koelen, Jorien
- Kuryk, Lukasz
- Lipiec, Agnieszka
- Greber, Urs F
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Free Access at
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Publisher DOI
Citations
Hendrickx, R., Stichling, N., Koelen, J., Kuryk, L., Lipiec, A., & Greber, U. F. (2014). Innate Immunity to Adenovirus. Human Gene Therapy, 25(4), 265–284. https://doi.org/10.1089/hum.2014.001
