Publication: The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy
The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy
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Neidert, M. C., Kowalewski, D. J., Silginer, M., et al, & Weller, M. (2018). The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy. Acta Neuropathologica, 135(6), 923–938. https://doi.org/10.1007/s00401-018-1836-9
Abstract
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Abstract
Glioblastoma is the most frequent malignant primary brain tumor. In a hierarchical tumor model, glioblastoma stem-like cells (GSC) play a major role in tumor initiation and maintenance as well as in therapy resistance and recurrence. Thus, targeting this cellular subset may be key to effective immunotherapy. Here, we present a mass spectrometry-based analysis of HLA-presented peptidomes of GSC and glioblastoma patient specimens. Based on the analysis of patient samples (n = 9) and GSC (n = 3), we performed comparative HLA peptidome pr
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- Neidert, Marian Christoph
- Kowalewski, Daniel Johannes
- Silginer, Manuela
- Weller, Michael
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Citations
Neidert, M. C., Kowalewski, D. J., Silginer, M., et al, & Weller, M. (2018). The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy. Acta Neuropathologica, 135(6), 923–938. https://doi.org/10.1007/s00401-018-1836-9
