A "Click Chemistry" approach to the efficient synthesis of multiple imaging probes derived from a single precursor

Mindt, T L; Müller, C; Stuker, F; Salazar, J F; Hohn, A; Mueggler, T; Rudin, M; Schibli, R

doi:10.1021/bc900276b

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Mindt, T. L., Müller, C., Stuker, F., Salazar, J. F., Hohn, A., Mueggler, T., Rudin, M., & Schibli, R. (2009). A “Click Chemistry” approach to the efficient synthesis of multiple imaging probes derived from a single precursor. Bioconjugate Chemistry, 20, 1940–1949. https://doi.org/10.1021/bc900276b

Abstract

Different imaging modalities can provide complementary information on biological processes at the cellular or molecular level in vitro and in vivo. However, specific molecular probes suitable for a comparison of different imaging modalities are often not readily accessible because their preparation is usually accomplished by individually developed and optimized syntheses. Herein, we present a general, modular synthetic approach that provides access to multiple probes derived from a single precursor by application of the same, efficien