Publication: NirA is an alternative nitrite reductase from Pseudomonas aeruginosa with potential as an antivirulence target
NirA is an alternative nitrite reductase from Pseudomonas aeruginosa with potential as an antivirulence target
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Fenn, S., Dubern, J.-F., Cigana, C., De Simone, M., Lazenby, J., Juhas, M., Schwager, S., Bianconi, I., Döring, G., Elmsley, J., Eberl, L., Williams, P., Bragonzi, A., & Cámara, M. (2021). NirA is an alternative nitrite reductase from Pseudomonas aeruginosa with potential as an antivirulence target. MBio, 12(2), e00207-21. https://doi.org/10.1128/mbio.00207-21
Abstract
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Abstract
The opportunistic pathogen Pseudomonas aeruginosa produces an arsenal of virulence factors causing a wide range of diseases in multiple hosts and is difficult to eradicate due to its intrinsic resistance to antibiotics. With the antibacterial pipeline drying up, antivirulence therapy has become an attractive alternative strategy to the traditional use of antibiotics to treat P. aeruginosa infections. To identify P. aeruginosa genes required for virulence in multiple hosts, a random library of Tn5 mutants in strain PAO1-L was previousl
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Creators (Authors)
- Fenn, Samuel
- Dubern, Jean-Frédéric
- Cigana, Cristina
- De Simone, Maura
- Lazenby, James
- Juhas, Mario
- Schwager, Stephan
- Bianconi, Irene
- Döring, Gerd
- Elmsley, Jonas
- Williams, Paul
- Bragonzi, Alessandra
- Cámara, Miguel
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Citations
Fenn, S., Dubern, J.-F., Cigana, C., De Simone, M., Lazenby, J., Juhas, M., Schwager, S., Bianconi, I., Döring, G., Elmsley, J., Eberl, L., Williams, P., Bragonzi, A., & Cámara, M. (2021). NirA is an alternative nitrite reductase from Pseudomonas aeruginosa with potential as an antivirulence target. MBio, 12(2), e00207-21. https://doi.org/10.1128/mbio.00207-21
