Developmental changes in gamma-aminobutyric acid levels in attention-deficit/hyperactivity disorder

Bollmann, Steffen; Ghisleni, Carmen; Poil, Simon-Shlomo; Martin, Ernst; Ball, J; Eich-Höchli, D; Edden, R A E; Klaver, Peter; Michels, Lars; Brandeis, Daniel; O'Gorman, Ruth L

doi:10.5167/uzh-111533

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Bollmann, S., Ghisleni, C., Poil, S.-S., Martin, E., Ball, J., Eich-Höchli, D., Edden, R. A. E., Klaver, P., Michels, L., Brandeis, D., & O’Gorman, R. L. (2015). Developmental changes in gamma-aminobutyric acid levels in attention-deficit/hyperactivity disorder. Translational Psychiatry, 5(6), e589. https://doi.org/10.1038/tp.2015.79

Abstract

While the neurobiological basis and developmental course of attention-deficit/hyperactivity disorder (ADHD) have not yet been fully established, an imbalance between inhibitory/excitatory neurotransmitters is thought to have an important role in the pathophysiology of ADHD. This study examined the changes in cerebral levels of GABA+, glutamate and glutamine in children and adults with ADHD using edited magnetic resonance spectroscopy. We studied 89 participants (16 children with ADHD, 19 control children, 16 adults with ADHD and 38 co