Publication: Inflammatory Wnt5A signalling pathways affecting barrier function of human vascular endothelial cells
Inflammatory Wnt5A signalling pathways affecting barrier function of human vascular endothelial cells
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Skaria, T., & Schoedon, G. (2017). Inflammatory Wnt5A signalling pathways affecting barrier function of human vascular endothelial cells. Journal of Inflammation, 14:15. https://doi.org/10.1186/s12950-017-0163-6
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Abstract
Wnt5A is a chemokine secreted by inflammatory-activated human macrophages that sustains their inflammatory response in an autocrine manner. High levels of Wnt5A are found in sera of patients with sepsis and septic shock. Here, we comment on recently reported Wnt5A signalling pathways in human vascular endothelial cells (VEC). In human VEC, Wnt5A regulates cytoskeleton remodelling and barrier function through Ryk receptor and Rho-associated protein serine/threonine kinase, targeting LIMK2 and CFL1 involved in actin polymerisation. Wnt5
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- Skaria, Tom
- Schoedon, Gabriele
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Skaria, T., & Schoedon, G. (2017). Inflammatory Wnt5A signalling pathways affecting barrier function of human vascular endothelial cells. Journal of Inflammation, 14:15. https://doi.org/10.1186/s12950-017-0163-6
