Publication: A clearer view of the molecular complexity of clear cell renal cell carcinoma
A clearer view of the molecular complexity of clear cell renal cell carcinoma
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Frew, I. J., & Moch, H. (2015). A clearer view of the molecular complexity of clear cell renal cell carcinoma. Annual Review of Pathology : Mechanisms of Disease, 10(1), 263–289. https://doi.org/10.1146/annurev-pathol-012414-040306
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The von Hippel-Lindau (VHL) tumor suppressor gene is mutated as an early event in almost all cases of clear cell renal cell carcinoma (ccRCC), the most frequent form of kidney cancer. In this review we discuss recent advances in understanding how dysregulation of the many hypoxia-inducible factor α-dependent and -independent functions of the VHL tumor suppressor protein (pVHL) can contribute to tumor initiation and progression. Recent evidence showing extensive inter- and intratumoral genetic diversity has given rise to the idea that
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- Frew, Ian J
- Moch, Holger
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Frew, I. J., & Moch, H. (2015). A clearer view of the molecular complexity of clear cell renal cell carcinoma. Annual Review of Pathology : Mechanisms of Disease, 10(1), 263–289. https://doi.org/10.1146/annurev-pathol-012414-040306
