Publication: Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants
Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants
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Vogt, S. B., Ley, L., Erne, L., Straumann, I., Becker, A. M., Klaiber, A., Holze, F., Vandersmissen, A., Mueller, L., Duthaler, U., Rudin, D., Luethi, D., Varghese, N., Eckert, A., & Liechti, M. E. (2023). Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants. Translational Psychiatry, 13(1), 172. https://doi.org/10.1038/s41398-023-02477-4
Abstract
Abstract
Abstract
N,N-dimethyltryptamine (DMT) is distinct among classic serotonergic psychedelics because of its short-lasting effects when administered intravenously. Despite growing interest in the experimental and therapeutic use of intravenous DMT, data are lacking on its clinical pharmacology. We conducted a double-blind, randomized, placebo-controlled crossover trial in 27 healthy participants to test different intravenous DMT administration regimens: placebo, low infusion (0.6 mg/min), high infusion (1 mg/min), low bolus + low infusion (15 mg +
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Creators (Authors)
- Vogt, Severin B
- Ley, Laura
- Erne, Livio
- Straumann, Isabelle
- Becker, Anna M
- Klaiber, Aaron
- Holze, Friederike
- Vandersmissen, Anja
- Mueller, Lorenz
- Duthaler, Urs
- Rudin, Deborah
- Luethi, Dino
- Varghese, Nimmy
- Eckert, Anne
- Liechti, Matthias E
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Vogt, S. B., Ley, L., Erne, L., Straumann, I., Becker, A. M., Klaiber, A., Holze, F., Vandersmissen, A., Mueller, L., Duthaler, U., Rudin, D., Luethi, D., Varghese, N., Eckert, A., & Liechti, M. E. (2023). Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants. Translational Psychiatry, 13(1), 172. https://doi.org/10.1038/s41398-023-02477-4
