Publication: Hepatocyte nuclear factor-4{alpha} and bile acids regulate human concentrative nucleoside transporter-1 gene expression
Hepatocyte nuclear factor-4{alpha} and bile acids regulate human concentrative nucleoside transporter-1 gene expression
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Klein, K., Kullak-Ublick, G. A., Wagner, M., Trauner, M., & Eloranta, J. J. (2009). Hepatocyte nuclear factor-4{alpha} and bile acids regulate human concentrative nucleoside transporter-1 gene expression. American Journal of Physiology. Gastrointestinal and Liver Physiology, 296(4), G936–G947. https://doi.org/10.1152/ajpgi.90678.2008
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The concentrative nucleoside transporter-1 (CNT1) is a member of the solute carrier 28 (SLC28) gene family, and is expressed in the liver, intestine, and kidneys. CNT1 mediates the uptake of naturally occurring pyrimidine nucleosides, but also nucleoside analogues used in anticancer and antiviral therapy. Thus, expression levels of CNT1 may affect the pharmacokinetics of these drugs and the outcome of drug therapy. Because little is known about the transcriptional regulation of human CNT1 gene expression, we have characterized the CNT
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- Klein, K
- Kullak-Ublick, G A
- Wagner, M
- Trauner, M
- Eloranta, J J
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Klein, K., Kullak-Ublick, G. A., Wagner, M., Trauner, M., & Eloranta, J. J. (2009). Hepatocyte nuclear factor-4{alpha} and bile acids regulate human concentrative nucleoside transporter-1 gene expression. American Journal of Physiology. Gastrointestinal and Liver Physiology, 296(4), G936–G947. https://doi.org/10.1152/ajpgi.90678.2008
