Publication: Distinct and regulated activities of human Gli proteins in Drosophila
Distinct and regulated activities of human Gli proteins in Drosophila
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von Mering, C., & Basler, K. (1999). Distinct and regulated activities of human Gli proteins in Drosophila. Current Biology, 9(22), 1319–1322. https://doi.org/10.1016/S0960-9822(00)80054-8
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Abstract
In both vertebrates and Drosophila, limb development is organized by a posteriorly located source of the signalling protein Hedgehog (Hh) [1] [2] [3] [4]. In Drosophila, the expression of Hh target genes is controlled by two opposing activities of the transcriptional regulator Cubitus interruptus (Ci), which activates target genes in response to Hh signalling but is converted into a repressor form in the absence of Hh [5] [6] [7] [8] [9] [10]. Three homologs of Ci (Gli1, Gli2, and Gli3) have been implicated in mediating responses to S
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von Mering, C., & Basler, K. (1999). Distinct and regulated activities of human Gli proteins in Drosophila. Current Biology, 9(22), 1319–1322. https://doi.org/10.1016/S0960-9822(00)80054-8