Publication: A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice
A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice
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Pierre-Ferrer, S., Collins, B., Lukacsovich, D., Wen, S., Cai, Y., Winterer, J., Yan, J., Pedersen, L., Földy, C., & Brown, S. A. (2024). A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice. Cell Reports, 43(5), 114220. https://doi.org/10.1016/j.celrep.2024.114220
Abstract
Abstract
Abstract
The suprachiasmatic nucleus (SCN) encodes time of day through changes in daily firing; however, the molecular mechanisms by which the SCN times behavior are not fully understood. To identify factors that could encode day/night differences in activity, we combine patch-clamp recordings and single-cell sequencing of individual SCN neurons in mice. We identify PiT2, a phosphate transporter, as being upregulated in a population of Vip+Nms+ SCN neurons at night. Although nocturnal and typically showing a peak of activity at lights off, mic
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Creators (Authors)
- Pierre-Ferrer, Sara
- Collins, Ben
- Lukacsovich, David
- Wen, Shao’Ang
- Cai, Yuchen
- Winterer, Jochen
- Yan, Jun
- Pedersen, Lene
- Földy, Csaba
- Brown, Steven A
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Citations
Pierre-Ferrer, S., Collins, B., Lukacsovich, D., Wen, S., Cai, Y., Winterer, J., Yan, J., Pedersen, L., Földy, C., & Brown, S. A. (2024). A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice. Cell Reports, 43(5), 114220. https://doi.org/10.1016/j.celrep.2024.114220
