Publication: Soft hydrogels featuring in-depth surface density gradients for the simple establishment of 3D tissue models for screening applications
Soft hydrogels featuring in-depth surface density gradients for the simple establishment of 3D tissue models for screening applications
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Zhang, N., Milleret, V., Thompson-Steckel, G., Huang, N.-P., Vörös, J., Simona, B. R., & Ehrbar, M. (2017). Soft hydrogels featuring in-depth surface density gradients for the simple establishment of 3D tissue models for screening applications. SLAS Discovery, 22(5), 635–644. https://doi.org/10.1177/2472555217693191
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Three-dimensional (3D) cell culture models are gaining increasing interest for use in drug development pipelines due to their closer resemblance to human tissues. Hydrogels are the first-choice class of materials to recreate in vitro the 3D extra-cellular matrix (ECM) environment, important in studying cell-ECM interactions and 3D cellular organization and leading to physiologically relevant in vitro tissue models. Here we propose a novel hydrogel platform consisting of a 96-well plate containing pre-cast synthetic PEG-based hydrogels
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- Zhang, Ning
- Milleret, Vincent
- Thompson-Steckel, Greta
- Huang, Ning-Ping
- Vörös, János
- Simona, Benjamin R
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Zhang, N., Milleret, V., Thompson-Steckel, G., Huang, N.-P., Vörös, J., Simona, B. R., & Ehrbar, M. (2017). Soft hydrogels featuring in-depth surface density gradients for the simple establishment of 3D tissue models for screening applications. SLAS Discovery, 22(5), 635–644. https://doi.org/10.1177/2472555217693191
