Publication: ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions
ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions
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Germic, N., Hosseini, A., Stojkov, D., Oberson, K., Claus, M., Benarafa, C., Calzavarini, S., Angelillo-Scherrer, A., Arnold, I. C., Müller, A., Riether, C., Yousefi, S., & Simon, H.-U. (2021). ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions. Blood, 137, 2958–2969. https://doi.org/10.1182/blood.2020010208
Abstract
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Abstract
Eosinophils are white blood cells that contribute to the regulation of immunity and are involved in the pathogenesis of numerous inflammatory diseases. In contrast to other cells of the immune system, no information is available regarding the role of autophagy in eosinophil differentiation and functions. To study the autophagic pathway in eosinophils, we generated conditional knockout mice in which Atg5 is deleted within the eosinophil lineage only (designated Atg5eoΔ mice). Eosinophilia was provoked by crossbreeding Atg5eoΔ mice with
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- Germic, Nina
- Hosseini, Aref
- Stojkov, Darko
- Oberson, Kevin
- Claus, Meike
- Benarafa, Charaf
- Calzavarini, Sara
- Angelillo-Scherrer, Anne
- Arnold, Isabelle C
- Riether, Carsten
- Yousefi, Shida
- Simon, Hans-Uwe
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Germic, N., Hosseini, A., Stojkov, D., Oberson, K., Claus, M., Benarafa, C., Calzavarini, S., Angelillo-Scherrer, A., Arnold, I. C., Müller, A., Riether, C., Yousefi, S., & Simon, H.-U. (2021). ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions. Blood, 137, 2958–2969. https://doi.org/10.1182/blood.2020010208
