Publication: Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1
Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1
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Pickel, C., Günter, J., Ruiz-Serrano, A., Spielmann, P., Fabrizio, J.-A., Wolski, W., Peet, D. J., Wenger, R. H., & Scholz, C. C. (2019). Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1. Redox Biology, 26, 101265. https://doi.org/10.1016/j.redox.2019.101265
Abstract
Abstract
Abstract
Protein:protein interactions are the basis of molecular communication and are usually of transient non-covalent nature, while covalent interactions other than ubiquitination are rare. For cellular adaptations, the cellular oxygen and peroxide sensor factor inhibiting HIF (FIH) confers oxygen and oxidant stress sensitivity to the hypoxia inducible factor (HIF) by asparagine hydroxylation. We investigated whether FIH contributes to hypoxia adaptation also through other mechanisms and identified a hypoxia sensitive, likely covalent, bond
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Creators (Authors)
- Pickel, Christina
- Günter, Julia
- Ruiz-Serrano, Amalia
- Spielmann, Patrick
- Fabrizio, Jacqueline-Alba
- Wolski, Witold
- Peet, Daniel J
- Wenger, Roland H
- Scholz, Carsten C
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Citations
Pickel, C., Günter, J., Ruiz-Serrano, A., Spielmann, P., Fabrizio, J.-A., Wolski, W., Peet, D. J., Wenger, R. H., & Scholz, C. C. (2019). Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1. Redox Biology, 26, 101265. https://doi.org/10.1016/j.redox.2019.101265
