Publication: Bioengineering of Fetal Skin: Differentiation of Amniotic Fluid Stem Cells into Keratinocytes
Bioengineering of Fetal Skin: Differentiation of Amniotic Fluid Stem Cells into Keratinocytes
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Citations
Basler, M., Pontiggia, L., Biedermann, T., Reichmann, E., Meuli, M., & Mazzone, L. (2020). Bioengineering of Fetal Skin: Differentiation of Amniotic Fluid Stem Cells into Keratinocytes. Fetal Diagnosis and Therapy, 47(3), 198–204. https://doi.org/10.1159/000502181
Abstract
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PURPOSE
Open fetal spina bifida repair has become a novel clinical standard of care. In very large spina bifida lesions, the skin defect cannot be covered primarily, asking for alternative solutions. We hypothesize that amniotic fluid stem cells (AFSC) could be differentiated into keratinocytes that could then be used to bioengineer autologous skin usable for in utero back coverage.
METHODS
To obtain human AFSC, amniotic fluid samples obtained from fetal surgeries were subjected to immunoselection for c-kit. C-kit-positive samples
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Creators (Authors)
- Basler, Michelle
- Biedermann, Thomas
- Reichmann, Ernst
- Meuli, Martin
- Mazzone, Luca
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Citations
Basler, M., Pontiggia, L., Biedermann, T., Reichmann, E., Meuli, M., & Mazzone, L. (2020). Bioengineering of Fetal Skin: Differentiation of Amniotic Fluid Stem Cells into Keratinocytes. Fetal Diagnosis and Therapy, 47(3), 198–204. https://doi.org/10.1159/000502181
