Publication: Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection
Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection
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Brügger, M., Démoulins, T., Barut, G. T., Zumkehr, B., Oliveira Esteves, B. I., Mehinagic, K., Haas, Q., Schögler, A., Rameix-Welti, M.-A., Eléouët, J.-F., Moehrlen, U., Marti, T. M., Schmid, R. A., Summerfield, A., Posthaus, H., Ruggli, N., Hall, S. R. R., & Alves, M. P. (2021). Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. PLoS Pathogens, 17(7), e1009789. https://doi.org/10.1371/journal.ppat.1009789
Abstract
Abstract
Abstract
Lung-resident (LR) mesenchymal stem and stromal cells (MSCs) are key elements of the alveolar niche and fundamental regulators of homeostasis and regeneration. We interrogated their function during virus-induced lung injury using the highly prevalent respiratory syncytial virus (RSV) which causes severe outcomes in infants. We applied complementary approaches with primary pediatric LR-MSCs and a state-of-the-art model of human RSV infection in lamb. Remarkably, RSV-infection of pediatric LR-MSCs led to a robust activation, characteriz
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- Brügger, Melanie
- Démoulins, Thomas
- Barut, G Tuba
- Zumkehr, Beatrice
- Oliveira Esteves, Blandina I
- Mehinagic, Kemal
- Haas, Quentin
- Schögler, Aline
- Rameix-Welti, Marie-Anne
- Eléouët, Jean-François
- Moehrlen, Ueli
- Marti, Thomas M
- Schmid, Ralph A
- Summerfield, Artur
- Posthaus, Horst
- Ruggli, Nicolas
- Hall, Sean R R
- Alves, Marco P
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Brügger, M., Démoulins, T., Barut, G. T., Zumkehr, B., Oliveira Esteves, B. I., Mehinagic, K., Haas, Q., Schögler, A., Rameix-Welti, M.-A., Eléouët, J.-F., Moehrlen, U., Marti, T. M., Schmid, R. A., Summerfield, A., Posthaus, H., Ruggli, N., Hall, S. R. R., & Alves, M. P. (2021). Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. PLoS Pathogens, 17(7), e1009789. https://doi.org/10.1371/journal.ppat.1009789
