Publication: Functional plasticity of the N-methyl-D-aspartate receptor in differentiating human erythroid precursor cells
Functional plasticity of the N-methyl-D-aspartate receptor in differentiating human erythroid precursor cells
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Hanggi, P., Telezhkin, V., Kemp, P. J., Schmugge, M., Gassmann, M., Goede, J. S., Speer, O., & Bogdanova, A. (2015). Functional plasticity of the N-methyl-D-aspartate receptor in differentiating human erythroid precursor cells. American Journal of Physiology. Cell Physiology, 308(12), C993–C1007. https://doi.org/10.1152/ajpcell.00395.2014
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Calcium signaling is essential to support erythroid proliferation and differentiation. Precise control of the intracellular Ca(2+) levels in erythroid precursor cells (EPCs) is afforded by coordinated expression and function of several cation channels, including the recently identified N methyl D aspartate receptor (NMDAR). Here, we characterized the changes in Ca(2+) uptake and electric currents mediated by the NMDARs occurring during EPC differentiation using flow cytometry and patch clamp. During erythropoietic maturation, subunit
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Creators (Authors)
- Hanggi, Pascal
- Telezhkin, Vsevolod
- Kemp, Paul J
- Schmugge, Markus
- Gassmann, Max
- Goede, Jeroen S
- Speer, Oliver
- Bogdanova, Anna
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Citations
Hanggi, P., Telezhkin, V., Kemp, P. J., Schmugge, M., Gassmann, M., Goede, J. S., Speer, O., & Bogdanova, A. (2015). Functional plasticity of the N-methyl-D-aspartate receptor in differentiating human erythroid precursor cells. American Journal of Physiology. Cell Physiology, 308(12), C993–C1007. https://doi.org/10.1152/ajpcell.00395.2014
