Publication: Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors
Date
Date
Date
Citations
Ralvenius, W. T., Neumann, E., Pagani, M., Acuña, M. A., Wildner, H., Benke, D., Fischer, N., Rostaher, A., Schwager, S., Detmar, M., Frauenknecht, K., Aguzzi, A., Hubbs, J. L., Rudolph, U., Favrot, C., & Zeilhofer, H. U. (2018). Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors. Nature Communications, 9(1), 3230. https://doi.org/10.1038/s41467-018-05709-0
Abstract
Abstract
Abstract
Chronic itch is a highly debilitating condition affecting about 10% of the general population. The relay of itch signals is under tight control by inhibitory circuits of the spinal dorsal horn, which may offer a hitherto unexploited therapeutic opportunity. Here, we found that specific pharmacological targeting of inhibitory α2 and α3GABAA receptors reduces acute histaminergic and non-histaminergic itch in mice. Systemic treatment with an α2/α3GABAA receptor selective modulator alleviates also chronic itch in a mouse model of atopic d
Additional indexing
Creators (Authors)
- Ralvenius, William T
- Neumann, Elena
- Pagani, Martina
- Acuña, Mario A
- Wildner, Hendrik
- Benke, Dietmar
- Fischer, Nina
- Rostaher, Ana
- Schwager, Simon
- Detmar, Michael
- Frauenknecht, Katrin
- Hubbs, Jed Lee
- Rudolph, Uwe
- Favrot, Claude
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Citations
Ralvenius, W. T., Neumann, E., Pagani, M., Acuña, M. A., Wildner, H., Benke, D., Fischer, N., Rostaher, A., Schwager, S., Detmar, M., Frauenknecht, K., Aguzzi, A., Hubbs, J. L., Rudolph, U., Favrot, C., & Zeilhofer, H. U. (2018). Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors. Nature Communications, 9(1), 3230. https://doi.org/10.1038/s41467-018-05709-0
