Vascular Endothelial Growth Factor A and VEGFR-1 change during preimplantation in Heifers

Chiumia, Daniel; Hankele, Anna-Katharina; Groebner, Anna E; Schulke, Katy; Reichenbach, Horst-Dieter; Giller, Katrin; Zakhartchenko, Valeri; Bauersachs, Stefan; Ulbrich, Susanne E

doi:10.5167/uzh-190850

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Chiumia, D., Hankele, A.-K., Groebner, A. E., Schulke, K., Reichenbach, H.-D., Giller, K., Zakhartchenko, V., Bauersachs, S., & Ulbrich, S. E. (2020). Vascular Endothelial Growth Factor A and VEGFR-1 change during preimplantation in Heifers. International Journal of Molecular Sciences, 21, 544. https://doi.org/10.3390/ijms21020544

Abstract

Vascular endothelial growth factor A (VEGFA) plays a critical angiogenic role in the endometrium of placentalia during preimplantation. The role of VEGFA and its receptors is not fully characterised in bovine reproduction. We analysed the mRNA expression of VEGFA isoforms 121, 165 and 189, and VEGF receptors 1 and 2 in three experimental settings (A, B and C). We compared intercaruncular endometrium of cyclic to pregnant heifers at Days 12, 15 and 18 post insemination (Day 0), and between Day 15 and Day 18 conceptuses (A). We further