Publication: Shedding Light on the Transcriptomic Dark Matter in Biological Psychiatry: Role of Long Noncoding RNAs in D-cycloserine-Induced Fear Extinction in Posttraumatic Stress Disorder
Shedding Light on the Transcriptomic Dark Matter in Biological Psychiatry: Role of Long Noncoding RNAs in D-cycloserine-Induced Fear Extinction in Posttraumatic Stress Disorder
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Malan-Müller, S., de Souza, V. B. C., Daniels, W. M. U., Seedat, S., Robinson, M. D., & Hemmings, S. M. J. (2020). Shedding Light on the Transcriptomic Dark Matter in Biological Psychiatry: Role of Long Noncoding RNAs in D-cycloserine-Induced Fear Extinction in Posttraumatic Stress Disorder. Omics : A Journal of Integrative Biology, 24(6), 352–369. https://doi.org/10.1089/omi.2020.0031
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Biological psychiatry scholarship on posttraumatic stress disorder (PTSD) is making strides with new omics technologies. In this context, there is growing recognition that noncoding RNAs are vital for the regulation of gene and protein expression. Long noncoding RNAs (lncRNAs) can modulate splicing, influence RNA editing, messenger RNA (mRNA) stability, translation activation, and microRNA–mRNA interactions, are highly abundant in the brain, and have been implicated in neurodevelopmental disorders. The largest subclass of lncRNAs is l
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Creators (Authors)
- Malan-Müller, Stefanie
- de Souza, Vladimir B C
- Daniels, Willie M U
- Seedat, Soraya
- Hemmings, Sîan M J
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Citations
Malan-Müller, S., de Souza, V. B. C., Daniels, W. M. U., Seedat, S., Robinson, M. D., & Hemmings, S. M. J. (2020). Shedding Light on the Transcriptomic Dark Matter in Biological Psychiatry: Role of Long Noncoding RNAs in D-cycloserine-Induced Fear Extinction in Posttraumatic Stress Disorder. Omics : A Journal of Integrative Biology, 24(6), 352–369. https://doi.org/10.1089/omi.2020.0031
