Publication: Sevoflurane sedation attenuates early cerebral oedema formation through stabilisation of the adherens junction protein beta catenin in a model of subarachnoid haemorrhage : A randomised animal study
Sevoflurane sedation attenuates early cerebral oedema formation through stabilisation of the adherens junction protein beta catenin in a model of subarachnoid haemorrhage : A randomised animal study
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Beck-Schimmer, B., Restin, T., Muroi, C., Roth Z’Graggen, B., Keller, E., & Schläpfer, M. (2020). Sevoflurane sedation attenuates early cerebral oedema formation through stabilisation of the adherens junction protein beta catenin in a model of subarachnoid haemorrhage : A randomised animal study. European Journal of Anaesthesiology, 37(5), 402–412. https://doi.org/10.1097/eja.0000000000001161
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BACKGROUND: Severe neurological impairment is a problem after subarachnoid haemorrhage (SAH). Although volatile anaesthetics, such as sevoflurane, have demonstrated protective properties in many organs, their use in cerebral injury is controversial. Cerebral vasodilation may lead to increased intracranial pressure (ICP), but at the same time volatile anaesthetics are known to stabilise the SAH-injured endothelial barrier. OBJECTIVE: To test the effect of sevoflurane on ICP and blood–brain barrier function. DESIGN: Randomised study. PA
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- Beck-Schimmer, Beatrice
- Restin, Tanja
- Muroi, Carl
- Roth Z’Graggen, Birgit
- Schläpfer, Martin
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Beck-Schimmer, B., Restin, T., Muroi, C., Roth Z’Graggen, B., Keller, E., & Schläpfer, M. (2020). Sevoflurane sedation attenuates early cerebral oedema formation through stabilisation of the adherens junction protein beta catenin in a model of subarachnoid haemorrhage : A randomised animal study. European Journal of Anaesthesiology, 37(5), 402–412. https://doi.org/10.1097/eja.0000000000001161
