Publication: Differential Localization and Functional Roles of mGluR6 Paralogs in Zebrafish Retina
Differential Localization and Functional Roles of mGluR6 Paralogs in Zebrafish Retina
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Haug, M., Haddad-Velioglu, S. A., Berger, M., Enz, A., Zang, J., & Neuhauss, S. C. F. (2024). Differential Localization and Functional Roles of mGluR6 Paralogs in Zebrafish Retina. Investigative Ophthalmology & Visual Science, 65(12), 44. https://doi.org/10.1167/iovs.65.12.44
Abstract
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Abstract
Purpose: To define the location of mglur6 paralogs in the outer zebrafish retina and delineate their contribution to retina light responses across the visual spectrum. Methods: In situ hybridization and immunolocalization with custom-made antibodies were used to localize mglur6 transcripts, proteins, and additional components of the mGluR6 signaling complex. Gene editing was used to generate knockout mutants that were analyzed with white light and spectral electroretinography. Results: Both mglur6 paralogs colocalized with known downs
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- Haug, Marion
- Haddad-Velioglu, Sara A
- Berger, Manuela
- Enz, Anjsa
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Haug, M., Haddad-Velioglu, S. A., Berger, M., Enz, A., Zang, J., & Neuhauss, S. C. F. (2024). Differential Localization and Functional Roles of mGluR6 Paralogs in Zebrafish Retina. Investigative Ophthalmology & Visual Science, 65(12), 44. https://doi.org/10.1167/iovs.65.12.44
