Publication: The HRDC domain of BLM is required for the dissolution of double Holliday junctions
The HRDC domain of BLM is required for the dissolution of double Holliday junctions
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Wu, L., Chan, K. L., Ralf, C., Bernstein, D. A., Garcia, P. L., Bohr, V., Vindigni, A., Janscak, P., Keck, J. L., & Hickson, I. D. (2005). The HRDC domain of BLM is required for the dissolution of double Holliday junctions. The EMBO Journal, 24, 2679–2687. https://doi.org/10.1038/sj.emboj.7600740
Abstract
Abstract
Abstract
Bloom's syndrome is a hereditary cancer-predisposition disorder resulting from mutations in the BLM gene. In humans, BLM encodes one of five members of the RecQ helicase family. One function of BLM is to act in concert with topoisomerase IIIalpha (TOPO IIIalpha) to resolve recombination intermediates containing double Holliday junctions by a process called double Holliday junction dissolution, herein termed dissolution. Here, we show that dissolution is highly specific for BLM among human RecQ helicases and critically depends upon a f
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Creators (Authors)
- Wu, L
- Chan, K L
- Ralf, C
- Bernstein, D A
- Garcia, P L
- Vindigni, A
- Janscak, Pavel
- Keck, J L
- Hickson, I D
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Citations
Wu, L., Chan, K. L., Ralf, C., Bernstein, D. A., Garcia, P. L., Bohr, V., Vindigni, A., Janscak, P., Keck, J. L., & Hickson, I. D. (2005). The HRDC domain of BLM is required for the dissolution of double Holliday junctions. The EMBO Journal, 24, 2679–2687. https://doi.org/10.1038/sj.emboj.7600740
