Publication: Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops
Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops
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Chappidi, N., Nascakova, Z., Boleslavska, B., Zellweger, R., Isik, E., Andrs, M., Menon, S., Dobrovolna, J., Balbo Pogliano, C., Matos, J., Porro, A., Lopes, M., & Janscak, P. (2020). Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops. Molecular Cell, 77(3), 528-541.e8. https://doi.org/10.1016/j.molcel.2019.10.026
Abstract
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Abstract
Formation of co-transcriptional R-loops underlies replication fork stalling upon head-on transcription-replication encounters. Here, we demonstrate that RAD51-dependent replication fork reversal induced by R-loops is followed by the restart of semiconservative DNA replication mediated by RECQ1 and RECQ5 helicases, MUS81/EME1 endonuclease, RAD52 strand-annealing factor, the DNA ligase IV (LIG4)/XRCC4 complex, and the non-catalytic subunit of DNA polymerase δ, POLD3. RECQ5 disrupts RAD51 filaments assembled on stalled forks after RECQ1-
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- Chappidi, Nagaraja
- Nascakova, Zuzana
- Boleslavska, Barbora
- Zellweger, Ralph
- Isik, Esin
- Andrs, Martin
- Menon, Shruti
- Dobrovolna, Jana
- Balbo Pogliano, Chiara
- Matos, Joao
- Porro, Antonio
- Lopes, Massimo
- Janscak, Pavel
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Chappidi, N., Nascakova, Z., Boleslavska, B., Zellweger, R., Isik, E., Andrs, M., Menon, S., Dobrovolna, J., Balbo Pogliano, C., Matos, J., Porro, A., Lopes, M., & Janscak, P. (2020). Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops. Molecular Cell, 77(3), 528-541.e8. https://doi.org/10.1016/j.molcel.2019.10.026
