Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia

Müller-Edenborn, Björn; Kania, Gabriela; Osto, Elena; Jakob, Philipp; Krasniqi, Nazmi; Beck-Schimmer, Beatrice; Blyszczuk, Przemyslaw; Eriksson, Urs

doi:10.1371/journal.pone.0154699

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Müller-Edenborn, B., Kania, G., Osto, E., Jakob, P., Krasniqi, N., Beck-Schimmer, B., Blyszczuk, P., & Eriksson, U. (2016). Lidocaine Enhances Contractile Function of Ischemic Myocardial Regions in Mouse Model of Sustained Myocardial Ischemia. PLoS ONE, 11(5), e0154699. https://doi.org/10.1371/journal.pone.0154699

Abstract

RATIONALE Perioperative myocardial ischemia is common in high-risk patients. The use of interventional revascularisation or even thrombolysis is limited in this patient subset due to exceedingly high bleeding risks. Blockade of voltage-gated sodium channels (VGSC) with lidocaine had been suggested to reduce infarct size and cardiomyocyte cell death in ischemia/reperfusion models. However, the impact of lidocaine on cardiac function during sustained ischemia still remains unclear. METHODS Sustained myocardial ischemia was induced by