Characterization and Comparison of Two Known Mutations in Protease-Activated Receptors (PAR4 Ala120Thr and PAR2 Ala118Thr)

Abstract

Introduction: Protease-activated receptors (PARs) play an essential role in the human bloodstream. They are involved in coagulation and barrier function as well as in upregulation of inflammation. Four PARs are known in humans, namely PAR1-4. A wellknown mutation located in PAR4, Ala120Thr, seems to be important in coagulation as it was shown that people with this single nucleotide polymorphism have an increased activation of blood platelets by the protease thrombin and leading to more cardiovascular events. Interestingly, a similar m Show more