Publication: Lack of paraoxonase 1 alters phospholipid composition, but not morphology and function of the mouse retina
Lack of paraoxonase 1 alters phospholipid composition, but not morphology and function of the mouse retina
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Oczos, J., Sutter, I., Kloeckener-Gruissem, B., Berger, W., Riwanto, M., Rentsch, K., Hornemann, T., von Eckardstein, A., & Grimm, C. (2014). Lack of paraoxonase 1 alters phospholipid composition, but not morphology and function of the mouse retina. Investigative Ophthalmology & Visual Science [IOVS], 55(8), 4714–4727. https://doi.org/10.1167/iovs.14-14332
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PURPOSE: Biochemical and genetic analyses established a contribution of lipid metabolism to AMD pathology. Paraoxonase 1 (PON1) is an antioxidative protein involved in high density lipoprotein (HDL) function and was found to be associated with AMD. Here, we used Pon1(-/-) mice to study the influence of PON1 on retinal physiology and to reveal the potential impact of PON1 on AMD etiology. METHODS: Laser capture microdissection served to isolate single retinal layers. Retinal function was assessed by ERG. Retinal and RPE morphology were
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- Oczos, J
- Sutter, I
- Kloeckener-Gruissem, B
- Berger, W
- Riwanto, M
- Rentsch, K
- Hornemann, T
- von Eckardstein, A
- Grimm, C
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Oczos, J., Sutter, I., Kloeckener-Gruissem, B., Berger, W., Riwanto, M., Rentsch, K., Hornemann, T., von Eckardstein, A., & Grimm, C. (2014). Lack of paraoxonase 1 alters phospholipid composition, but not morphology and function of the mouse retina. Investigative Ophthalmology & Visual Science [IOVS], 55(8), 4714–4727. https://doi.org/10.1167/iovs.14-14332
