Publication: Control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium
Control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium
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Mytlis, A., Kumar, V., Qiu, T., Deis, R., Hart, N., Levy, K., Masek, M., Shawahny, A., Ahmad, A., Eitan, H., Nather, F., Adar-Levor, S., Birnbaum, R. Y., Elia, N., Bachmann-Gagescu, R., Roy, S., & Elkouby, Y. M. (2022). Control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium. Science, 376, 6599. https://doi.org/10.1126/science.abh3104
Abstract
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Abstract
A hallmark of meiosis is chromosomal pairing, which requires telomere tethering and rotation on the nuclear envelope through microtubules, driving chromosome homology searches. Telomere pulling toward the centrosome forms the “zygotene chromosomal bouquet.” Here, we identified the “zygotene cilium” in oocytes. This cilium provides a cable system for the bouquet machinery and extends throughout the germline cyst. Using zebrafish mutants and live manipulations, we demonstrate that the cilium anchors the centrosome to counterbalance telo
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- Mytlis, Avishag
- Kumar, Vineet
- Qiu, Tao
- Deis, Rachael
- Hart, Neta
- Levy, Karine
- Masek, Markus
- Shawahny, Amal
- Ahmad, Adam
- Eitan, Hagai
- Nather, Farouq
- Adar-Levor, Shai
- Birnbaum, Ramon Y
- Elia, Natalie
- Roy, Sudipto
- Elkouby, Yaniv M
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Mytlis, A., Kumar, V., Qiu, T., Deis, R., Hart, N., Levy, K., Masek, M., Shawahny, A., Ahmad, A., Eitan, H., Nather, F., Adar-Levor, S., Birnbaum, R. Y., Elia, N., Bachmann-Gagescu, R., Roy, S., & Elkouby, Y. M. (2022). Control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium. Science, 376, 6599. https://doi.org/10.1126/science.abh3104
