Publication: Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death
Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death
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Wernlé, K. K., Sonnenfelt, M. A., Leek, C. C., Ganji, E., Sullivan, A. L., Offutt, C., Shuff, J., Ornitz, D. M., & Killian, M. L. (2023). Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death. Developmental Dynamics, 252(9), 1180–1188. https://doi.org/10.1002/dvdy.600
Abstract
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BACKGROUND
Tendons and ligaments attach to bone are essential for joint mobility and stability in vertebrates. Tendon and ligament attachments (ie, entheses) are found at bony protrusions (ie, eminences), and the shape and size of these protrusions depend on both mechanical forces and cellular cues during growth. Tendon eminences also contribute to mechanical leverage for skeletal muscle. Fibroblast growth factor receptor (FGFR) signaling plays a critical role in bone development, and Fgfr1 and Fgfr2 are highly expressed in the peric
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- Wernlé, Kendra K
- Sonnenfelt, Michael A
- Leek, Connor C
- Ganji, Elahe
- Sullivan, Anna Lia
- Offutt, Claudia
- Shuff, Jordan
- Ornitz, David M
- Killian, Megan L
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Wernlé, K. K., Sonnenfelt, M. A., Leek, C. C., Ganji, E., Sullivan, A. L., Offutt, C., Shuff, J., Ornitz, D. M., & Killian, M. L. (2023). Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death. Developmental Dynamics, 252(9), 1180–1188. https://doi.org/10.1002/dvdy.600
