Publication: Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma
Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma
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Capdeville, C., Russo, L., Penton, D., Migliavacca, J., Zecevic, M., Gries, A., Neuhauss, S. C. F., Grotzer, M. A., & Baumgartner, M. (2022). Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma. Life Science Alliance, 5(6), e202201380. https://doi.org/10.26508/lsa.202201380
Abstract
Abstract
Abstract
The composition of the plasma membrane (PM)-associated proteome of tumor cells determines cell-cell and cell-matrix interactions and the response to environmental cues. Whether the PM-associated proteome impacts the phenotype of Medulloblastoma (MB) tumor cells and how it adapts in response to growth factor cues is poorly understood. Using a spatial proteomics approach, we observed that hepatocyte growth factor (HGF)-induced activation of the receptor tyrosine kinase c-MET in MB cells changes the abundance of transmembrane and membran
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Creators (Authors)
- Capdeville, Charles
- Russo, Linda
- Penton, David
- Migliavacca, Jessica
- Zecevic, Milica
- Gries, Alexandre
- Grotzer, Michael A
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Citations
Capdeville, C., Russo, L., Penton, D., Migliavacca, J., Zecevic, M., Gries, A., Neuhauss, S. C. F., Grotzer, M. A., & Baumgartner, M. (2022). Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma. Life Science Alliance, 5(6), e202201380. https://doi.org/10.26508/lsa.202201380
