Publication: Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis
Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis
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Rufener, R., Ritler, D., Zielinski, J., Dick, L., da Silva, E. T., da Silva Araujo, A., Joekel, D. E., Czock, D., Goepfert, C., Moraes, A. M., de Souza, M. V. N., Müller, J., Mevissen, M., Hemphill, A., & Lundström-Stadelmann, B. (2018). Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. International Journal for Parasitology: Drugs and Drug Resistance, 8(2), 331–340. https://doi.org/10.1016/j.ijpddr.2018.06.004
Abstract
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Abstract
The cestode E. multilocularis causes the disease alveolar echinococcosis (AE) in humans. The continuously proliferating metacestode (larval stage) of the parasite infects mostly the liver and exhibits tumor-like growth. Current chemotherapeutical treatment options rely on benzimidazoles, which are rarely curative and have to be applied daily and life-long. This can result in considerable hepatotoxicity and thus treatment discontinuation. Therefore, novel drugs against AE are urgently needed. The anti-malarial mefloquine was previously
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Creators (Authors)
- Rufener, Reto
- Ritler, Dominic
- Zielinski, Jana
- Dick, Luca
- da Silva, Emerson Teixeira
- da Silva Araujo, Adriele
- Joekel, Deborah Elisabeth
- Czock, David
- Goepfert, Christine
- Moraes, Adriana Marques
- de Souza, Marcus Vinicius Nora
- Müller, Joachim
- Mevissen, Meike
- Hemphill, Andrew
- Lundström-Stadelmann, Britta
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Citations
Rufener, R., Ritler, D., Zielinski, J., Dick, L., da Silva, E. T., da Silva Araujo, A., Joekel, D. E., Czock, D., Goepfert, C., Moraes, A. M., de Souza, M. V. N., Müller, J., Mevissen, M., Hemphill, A., & Lundström-Stadelmann, B. (2018). Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. International Journal for Parasitology: Drugs and Drug Resistance, 8(2), 331–340. https://doi.org/10.1016/j.ijpddr.2018.06.004
