Publication: Highly sensitive reporter cell line for detection of interferon types I-III and their neutralization by antibodies
Highly sensitive reporter cell line for detection of interferon types I-III and their neutralization by antibodies
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Groen, K., Kuratli, R., Sar, L., Vasou, A., Huber, M., Hughes, D. J., & Hale, B. G. (2024). Highly sensitive reporter cell line for detection of interferon types I-III and their neutralization by antibodies. European Journal of Immunology, 54(12), e2451325. https://doi.org/10.1002/eji.202451325
Abstract
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Abstract
Interferons (IFNs) are a critical component of innate immune defenses and limit viral disease severity. To advance studies on IFNs and their neutralization by pathogenic autoantibodies, we generated a Renilla luciferase-based reporter cell line capable of detecting the activities of IFN-Is, IFN-II, and IFN-IIIs. The reporter cell line exhibits a 125- to 2000-fold higher sensitivity to IFNs than a commonly used alternative biological reporter system and allows for a rapid and simple live-cell workflow for detecting low titer amounts of
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- Groen, Kevin
- Kuratli, Roger
- Sar, Lauren
- Vasou, Andri
- Hughes, David J
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Groen, K., Kuratli, R., Sar, L., Vasou, A., Huber, M., Hughes, D. J., & Hale, B. G. (2024). Highly sensitive reporter cell line for detection of interferon types I-III and their neutralization by antibodies. European Journal of Immunology, 54(12), e2451325. https://doi.org/10.1002/eji.202451325
