Publication: Insulin resistance and increased lipolysis in bone marrow derived adipocytes stimulated with agonists of Toll-like receptors
Insulin resistance and increased lipolysis in bone marrow derived adipocytes stimulated with agonists of Toll-like receptors
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Franchini, M., Monnais, E., Seboek, D., Radimerski, T., Zini, E., Kaufmann, K., Lutz, T. A., Reusch, C. E., Ackermann, M., Muller, B., & Linscheid, P. (2010). Insulin resistance and increased lipolysis in bone marrow derived adipocytes stimulated with agonists of Toll-like receptors. Hormone and Metabolic Research, 42(10), 703–709. https://doi.org/10.1055/s-0030-1261872
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Our objectives were to identify Toll-like receptors (TLRs) in human bone marrow derived adipocytes, to test specific TLR agonists for their ability to induce a proinflammatory response, and to investigate possible metabolic effects after TLR activation, in particular, those associated with insulin resistance and lipolysis. Mesenchymal stem cells were isolated from human bone marrow and differentiated into adipocytes. Total RNA before or after stimulation with agonists specific for TLR was extracted for analysis of expression of TLRs p
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Franchini, M., Monnais, E., Seboek, D., Radimerski, T., Zini, E., Kaufmann, K., Lutz, T. A., Reusch, C. E., Ackermann, M., Muller, B., & Linscheid, P. (2010). Insulin resistance and increased lipolysis in bone marrow derived adipocytes stimulated with agonists of Toll-like receptors. Hormone and Metabolic Research, 42(10), 703–709. https://doi.org/10.1055/s-0030-1261872