Publication: Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway
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Wolf, M. J., Hoos, A., Bauer, J., Boettcher, S., Knust, M., Weber, A., Simonavicius, N., Schneider, C., Lang, M., Stürzl, M., Croner, R. S., Konrad, A., Manz, M. G., Moch, H., Aguzzi, A., van Loo, G., Pasparakis, M., Prinz, M., Borsig, L., & Heikenwalder, M. (2012). Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell, 22, 91–105. https://doi.org/10.1016/j.ccr.2012.05.023
Abstract
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Abstract
Increased expression of the chemokine CCL2 in tumor cells correlates with enhanced metastasis, poor prognosis, and recruitment of CCR2(+)Ly6C(hi) monocytes. However, the mechanisms driving tumor cell extravasation through the endothelium remain elusive. Here, we describe CCL2 upregulation in metastatic UICC stage IV colon carcinomas and demonstrate that tumor cell-derived CCL2 activates the CCR2(+) endothelium to increase vascular permeability in vivo. CCR2 deficiency prevents colon carcinoma extravasation and metastasis. Of note, CCR
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- Wolf, Monika Julia
- Hoos, Alexandra
- Bauer, Judith
- Boettcher, Steffen
- Knust, Markus
- Weber, Achim
- Simonavicius, Nicole
- Lang, Matthias
- Stürzl, Michael
- Croner, Roland S
- Konrad, Andreas
- Manz, Markus G
- Moch, Holger
- van Loo, Geert
- Pasparakis, Manolis
- Prinz, Marco
- Borsig, Lubor
- Heikenwalder, Mathias
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Publications of Institute of Neuropathology
Publications of Institute of Pathology and Molecular Pathology
Publications of Institute of Physiology
Publications of Institute of Physiology
Publications of Zurich Center for Integrative Human Physiology (ZIHP)
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Wolf, M. J., Hoos, A., Bauer, J., Boettcher, S., Knust, M., Weber, A., Simonavicius, N., Schneider, C., Lang, M., Stürzl, M., Croner, R. S., Konrad, A., Manz, M. G., Moch, H., Aguzzi, A., van Loo, G., Pasparakis, M., Prinz, M., Borsig, L., & Heikenwalder, M. (2012). Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell, 22, 91–105. https://doi.org/10.1016/j.ccr.2012.05.023
