Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study

Etter, Manina M; Martins, Tomás A; Kulsvehagen, Laila; Pössnecker, Elisabeth; Duchemin, Wandrille; Hogan, Sabrina; Sanabria-Diaz, Gretel; Müller, Jannis; Chiappini, Alessio; Rychen, Jonathan; Eberhard, Noëmi; Guzman, Raphael; Mariani, Luigi; Melie-Garcia, Lester; Keller, Emanuela; Jelcic, Ilijas; Pargger, Hans; Siegemund, Martin; Kuhle, Jens; Oechtering, Johanna

doi:10.1038/s41467-022-34068-0

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Etter, M. M., Martins, T. A., Kulsvehagen, L., Pössnecker, E., Duchemin, W., Hogan, S., Sanabria-Diaz, G., Müller, J., Chiappini, A., Rychen, J., Eberhard, N., Guzman, R., Mariani, L., Melie-Garcia, L., Keller, E., Jelcic, I., Pargger, H., Siegemund, M., Kuhle, J., … Hutter, G. (2022). Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study. Nature Communications, 13(1), 6777. https://doi.org/10.1038/s41467-022-34068-0

Abstract

Growing evidence links COVID-19 with acute and long-term neurological dysfunction. However, the pathophysiological mechanisms resulting in central nervous system involvement remain unclear, posing both diagnostic and therapeutic challenges. Here we show outcomes of a cross-sectional clinical study (NCT04472013) including clinical and imaging data and corresponding multidimensional characterization of immune mediators in the cerebrospinal fluid (CSF) and plasma of patients belonging to different Neuro-COVID severity classes. The most p