Publication: Activation of mTORC2 by Association with the Ribosome
Activation of mTORC2 by Association with the Ribosome
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Zinzalla, V., Stracka, D., Oppliger, W., & Hall, M. N. (2011). Activation of mTORC2 by Association with the Ribosome. Cell, 144, 757–768. https://doi.org/10.1016/j.cell.2011.02.014
Abstract
Abstract
Abstract
The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of growth. Mammalian TOR complex 2 (mTORC2) regulates AGC kinase family members and is implicated in various disorders, including cancer and diabetes. Here, we investigated the upstream regulation of mTORC2. A genetic screen in yeast and subsequent studies in mammalian cells revealed that ribosomes, but not protein synthesis, are required for mTORC2 signaling. Active mTORC2 was physically associated with the ribosome, and insulin-stimulated PI3
Additional indexing
Creators (Authors)
- Zinzalla, Vittoria
- Stracka, Daniele
- Oppliger, Wolfgang
- Hall, Michael N
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Citations
Zinzalla, V., Stracka, D., Oppliger, W., & Hall, M. N. (2011). Activation of mTORC2 by Association with the Ribosome. Cell, 144, 757–768. https://doi.org/10.1016/j.cell.2011.02.014
