Publication: Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas
Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas
Date
Date
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Citations
Chen, J., Sobecki, M., Krzywinska, E., Thierry, K., Masmoudi, M., Nagarajan, S., Fan, Z., He, J., Ferapontova, I., Nelius, E., Seehusen, F., Gotthardt, D., Takeda, N., Sommer, L., Sexl, V., Münz, C., DeNardo, D., Hennino, A., & Stockmann, C. (2024). Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas. EMBO Molecular Medicine, 16(12), 3033–3056. https://doi.org/10.1038/s44321-024-00157-4
Abstract
Abstract
Abstract
A hallmark feature of pancreatic ductal adenocarcinoma (PDAC) is massive intratumoral fibrosis, designated as desmoplasia. Desmoplasia is characterized by the expansion of cancer-associated fibroblasts (CAFs) and a massive increase in extracellular matrix (ECM). During fibrogenesis, distinct genes become reactivated specifically in fibroblasts, e.g., the disintegrin metalloprotease, ADAM12. Previous studies have shown that immunotherapeutic ablation of ADAM12$^{+}$
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Creators (Authors)
- Chen, Jing
- Sobecki, Michal
- Krzywinska, Ewelina
- Thierry, Kevin
- Masmoudi, Mélissa
- Nagarajan, Shunmugam
- Fan, Zheng
- He, Jingyi
- Ferapontova, Irina
- Nelius, Eric
- Seehusen, Frauke
- Gotthardt, Dagmar
- Takeda, Norihiko
- Sommer, Lukas
- Sexl, Veronika
- Münz, Christian
- DeNardo, David
- Hennino, Ana
- Stockmann, Christian
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Citations
Chen, J., Sobecki, M., Krzywinska, E., Thierry, K., Masmoudi, M., Nagarajan, S., Fan, Z., He, J., Ferapontova, I., Nelius, E., Seehusen, F., Gotthardt, D., Takeda, N., Sommer, L., Sexl, V., Münz, C., DeNardo, D., Hennino, A., & Stockmann, C. (2024). Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas. EMBO Molecular Medicine, 16(12), 3033–3056. https://doi.org/10.1038/s44321-024-00157-4
