Hemodynamic response to sensory stimulation in mice: Comparison between functional ultrasound and optoacoustic imaging

Robin, Justine; Rau, Richard; Lafci, Berkan; Schroeter, Aileen; Reiss, Michael; Deán-Ben, Xosé-Luís; Goksel, Orcun; Razansky, Daniel

doi:10.5167/uzh-216036

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Robin, J., Rau, R., Lafci, B., Schroeter, A., Reiss, M., Deán-Ben, X.-L., Goksel, O., & Razansky, D. (2021). Hemodynamic response to sensory stimulation in mice: Comparison between functional ultrasound and optoacoustic imaging. NeuroImage, 237, 118111. https://doi.org/10.1016/j.neuroimage.2021.118111

Abstract

Intense efforts are underway to develop functional imaging modalities for capturing brain activity at the whole organ scale with high spatial and temporal resolution. Functional optoacoustic (fOA) imaging is emerging as a new tool to monitor multiple hemodynamic parameters across the mouse brain, but its sound validation against other neuroimaging modalities is often lacking. Here we investigate mouse brain responses to peripheral sensory stimulation using both fOA and functional ultrasound (fUS) imaging. The two modalities operate un