Publication: Inferring clonal composition from multiple tumor biopsies
Inferring clonal composition from multiple tumor biopsies
Date
Date
Date
Citations
Manica, M., Kim, H. R., Mathis, R., Chouvarine, P., Rutishauser, D., De Vargas Roditi, L., Szalai, B., Wagner, U., Oehl, K., Saba, K., Pati, A., Saez-Rodriguez, J., Roy, A., Parsons, D. W., Wild, P. J., Martínez, M. R., & Sumazin, P. (2020). Inferring clonal composition from multiple tumor biopsies. NPJ Systems Biology and Applications, 6, 27. https://doi.org/10.1038/s41540-020-00147-5
Abstract
Abstract
Abstract
Knowledge about the clonal evolution of a tumor can help to interpret the function of its genetic alterations by identifying initiating events and events that contribute to the selective advantage of proliferative, metastatic, and drug-resistant subclones. Clonal evolution can be reconstructed from estimates of the relative abundance (frequency) of subclone-specific alterations in tumor biopsies, which, in turn, inform on its composition. However, estimating these frequencies is complicated by the high genetic instability that charact
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Creators (Authors)
- Manica, Matteo
- Kim, Hyunjae Ryan
- Mathis, Roland
- Chouvarine, Philippe
- Rutishauser, Dorothea
- De Vargas Roditi, Laura
- Szalai, Bence
- Wagner, Ulrich
- Oehl, Kathrin
- Saba, Karim
- Pati, Arati
- Saez-Rodriguez, Julio
- Roy, Angshumoy
- Parsons, Donald W
- Wild, Peter J
- Martínez, María Rodríguez
- Sumazin, Pavel
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Citations
Manica, M., Kim, H. R., Mathis, R., Chouvarine, P., Rutishauser, D., De Vargas Roditi, L., Szalai, B., Wagner, U., Oehl, K., Saba, K., Pati, A., Saez-Rodriguez, J., Roy, A., Parsons, D. W., Wild, P. J., Martínez, M. R., & Sumazin, P. (2020). Inferring clonal composition from multiple tumor biopsies. NPJ Systems Biology and Applications, 6, 27. https://doi.org/10.1038/s41540-020-00147-5
