Publication: Neuropilin-1 is a host factor for SARS-CoV-2 infection
Neuropilin-1 is a host factor for SARS-CoV-2 infection
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Daly, J. L., Simonetti, B., Klein, K., Chen, K.-E., Williamson, M. K., Antón-Plágaro, C., Shoemark, D. K., Simón-Gracia, L., Bauer, M., Hollandi, R., Greber, U. F., Horvath, P., Sessions, R. B., Helenius, A., Hiscox, J. A., Teesalu, T., Matthews, D. A., Davidson, A. D., Collins, B. M., … Yamauchi, Y. (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370(6518), 861–865. https://doi.org/10.1126/science.abd3072
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Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for host cell attachment and entry. The host protease furin cleaves the full-length precursor S glycoprotein into two associated polypeptides: S1 and S2. Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors. We used x-ray crystallography and
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Creators (Authors)
- Daly, James L
- Simonetti, Boris
- Klein, Katja
- Chen, Kai-En
- Williamson, Maia Kavanagh
- Antón-Plágaro, Carlos
- Shoemark, Deborah K
- Simón-Gracia, Lorena
- Bauer, Michael
- Hollandi, Reka
- Horvath, Peter
- Sessions, Richard B
- Helenius, Ari
- Hiscox, Julian A
- Teesalu, Tambet
- Matthews, David A
- Davidson, Andrew D
- Collins, Brett M
- Cullen, Peter J
- Yamauchi, Yohei
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Daly, J. L., Simonetti, B., Klein, K., Chen, K.-E., Williamson, M. K., Antón-Plágaro, C., Shoemark, D. K., Simón-Gracia, L., Bauer, M., Hollandi, R., Greber, U. F., Horvath, P., Sessions, R. B., Helenius, A., Hiscox, J. A., Teesalu, T., Matthews, D. A., Davidson, A. D., Collins, B. M., … Yamauchi, Y. (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370(6518), 861–865. https://doi.org/10.1126/science.abd3072
