C-Terminal-Pro-Endothelin-1 Adds Incremental Prognostic Value for Risk Stratification After Ischemic Stroke

Westphal, Laura P; Schweizer, Juliane; Fluri, Felix; De Marchis, Gian Marco; Christ-Crain, Mirjam; Luft, Andreas R; Katan, Mira

doi:10.3389/fneur.2020.629151

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Westphal, L. P., Schweizer, J., Fluri, F., De Marchis, G. M., Christ-Crain, M., Luft, A. R., & Katan, M. (2021). C-Terminal-Pro-Endothelin-1 Adds Incremental Prognostic Value for Risk Stratification After Ischemic Stroke. Frontiers in Neurology, 11, 629151. https://doi.org/10.3389/fneur.2020.629151

Abstract

Background and Aims: Endothelins have shown to play a role in the pathophysiology of ischemic stroke. We aimed at evaluating the incremental prognostic value of C-terminal-pro-endothelin-1 (CT-pro-ET-1) in a well-described cohort of acute stroke patients. Methods: We performed serial measurements of CT-pro-ET-1 in 361 consecutively enrolled ischemic stroke patients and assessed functional outcome and mortality after 90 days. As we found peak levels of CT-pro-ET-1 and the most prominent association with mortality on day 1 after admissi