Publication: Antigen-specific Th17 cells are primed by distinct and complementary dendritic cell subsets in oropharyngeal candidiasis
Antigen-specific Th17 cells are primed by distinct and complementary dendritic cell subsets in oropharyngeal candidiasis
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Trautwein-Weidner, K., Gladiator, A., Kirchner, F. R., Becattini, S., Rülicke, T., Sallusto, F., & LeibundGut-Landmann, S. (2015). Antigen-specific Th17 cells are primed by distinct and complementary dendritic cell subsets in oropharyngeal candidiasis. PLoS Pathogens, 11(10), e1005164. https://doi.org/10.1371/journal.ppat.1005164
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Candida spp. can cause severe and chronic mucocutaneous and systemic infections in immunocompromised individuals. Protection from mucocutaneous candidiasis depends on T helper cells, in particular those secreting IL-17. The events regulating T cell activation and differentiation toward effector fates in response to fungal invasion in different tissues are poorly understood. Here we generated a Candida-specific TCR transgenic mouse reactive to a novel endogenous antigen that is conserved in multiple distant species of Candida, includin
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- Trautwein-Weidner, Kerstin
- Gladiator, André
- Kirchner, Florian R
- Becattini, Simone
- Rülicke, Thomas
- Sallusto, Federica
- LeibundGut-Landmann, Salomé
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Trautwein-Weidner, K., Gladiator, A., Kirchner, F. R., Becattini, S., Rülicke, T., Sallusto, F., & LeibundGut-Landmann, S. (2015). Antigen-specific Th17 cells are primed by distinct and complementary dendritic cell subsets in oropharyngeal candidiasis. PLoS Pathogens, 11(10), e1005164. https://doi.org/10.1371/journal.ppat.1005164
