Publication: Preparation of fluorescent microcystin derivatives by direct arginine labelling and their biological evaluation
Preparation of fluorescent microcystin derivatives by direct arginine labelling and their biological evaluation
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Grundler, V., Faltermann, S., Fent, K., & Gademann, K. (2015). Preparation of fluorescent microcystin derivatives by direct arginine labelling and their biological evaluation. Chembiochem, 16(11), 1657–1662. https://doi.org/10.1002/cbic.201500181
Abstract
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Microcystin is the most prevalent toxin produced by cyanobacteria and poses a severe threat to livestock, humans and entire ecosystems. We report the preparation of a series of fluorescent microcystin derivatives by direct arginine labelling of the unprotected peptides at the guanidinium side chain. This new method allows a simple late-stage diversification strategy for native peptides devoid of protecting groups under mild conditions. A series of fluorophores were conjugated to microcystin-LR in good to very good yield. The fluoresce
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- Grundler, Verena
- Faltermann, Susanne
- Fent, Karl
- Gademann, Karl
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Grundler, V., Faltermann, S., Fent, K., & Gademann, K. (2015). Preparation of fluorescent microcystin derivatives by direct arginine labelling and their biological evaluation. Chembiochem, 16(11), 1657–1662. https://doi.org/10.1002/cbic.201500181
