Publication: Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure
Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure
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Smith, M. P., Rowling, E. J., Miskolczi, Z., Ferguson, J., Spoerri, L., Haass, N. K., Sloss, O., McEntegart, S., Arozarena, I., von Kriegsheim, A., Rodriguez, J., Brunton, H., Kmarashev, J., Levesque, M. P., Dummer, R., Frederick, D. T., Andrews, M. C., Cooper, Z. A., Flaherty, K. T., … Wellbrock, C. (2017). Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure. EMBO Molecular Medicine, 9, 1011–1029. https://doi.org/10.15252/emmm.201607156
Abstract
Abstract
Abstract
Approaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a "MITF-high" phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also contain subpopulations of the de novo resistance "AXL-high" phenotype. > 50% of melanomas progress with enriched "AXL-high" populations, and because AXL is linked to de-differentiation and invasiveness avoiding an "AXL-high relapse" is desirable. We discovered that phenotype heterogeneity is supported during
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Creators (Authors)
- Smith, Michael P
- Rowling, Emily J
- Miskolczi, Zsofia
- Ferguson, Jennifer
- Spoerri, Loredana
- Haass, Nikolas K
- Sloss, Olivia
- McEntegart, Sophie
- Arozarena, Imanol
- von Kriegsheim, Alex
- Rodriguez, Javier
- Brunton, Holly
- Kmarashev, Jivko
- Levesque, Mitchell P
- Dummer, Reinhard
- Frederick, Dennie T
- Andrews, Miles C
- Cooper, Zachary A
- Flaherty, Keith T
- Wargo, Jennifer A
- Wellbrock, Claudia
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Citations
Smith, M. P., Rowling, E. J., Miskolczi, Z., Ferguson, J., Spoerri, L., Haass, N. K., Sloss, O., McEntegart, S., Arozarena, I., von Kriegsheim, A., Rodriguez, J., Brunton, H., Kmarashev, J., Levesque, M. P., Dummer, R., Frederick, D. T., Andrews, M. C., Cooper, Z. A., Flaherty, K. T., … Wellbrock, C. (2017). Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure. EMBO Molecular Medicine, 9, 1011–1029. https://doi.org/10.15252/emmm.201607156
