Publication: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group
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Kim, B.-G., Kim, G., Abe, Y., Alonso, P., Ameis, S., Anticevic, A., Arnold, P. D., Balachander, S., Banaj, N., Bargalló, N., Batistuzzo, M. C., Benedetti, F., Bertolín, S., Beucke, J. C., Bollettini, I., Brem, S., Brennan, B. P., Buitelaar, J. K., Calvo, R., … et al. (2024). White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group. Molecular Psychiatry, 29(4), 1063–1074. https://doi.org/10.1038/s41380-023-02392-6
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White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175
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Kim, B.-G., Kim, G., Abe, Y., Alonso, P., Ameis, S., Anticevic, A., Arnold, P. D., Balachander, S., Banaj, N., Bargalló, N., Batistuzzo, M. C., Benedetti, F., Bertolín, S., Beucke, J. C., Bollettini, I., Brem, S., Brennan, B. P., Buitelaar, J. K., Calvo, R., … et al. (2024). White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group. Molecular Psychiatry, 29(4), 1063–1074. https://doi.org/10.1038/s41380-023-02392-6
