Publication: Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis
Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis
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Manogaran, P., Samardzija, M., Schad, A. N., Wicki, C. A., Walker-Egger, C., Rudin, M., Grimm, C., & Schippling, S. (2019). Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis. Acta Neuropathologica Communications, 7(1), 116. https://doi.org/10.1186/s40478-019-0768-5
Abstract
Abstract
Abstract
The exact mechanisms and temporal sequence of neurodegeneration in multiple sclerosis are still unresolved. The visual pathway including its unmyelinated retinal axons, can serve as a prototypic model of neurodegeneration in experimental optic neuritis. We conducted a longitudinal study combining retinal imaging through optical coherence tomography (OCT) with immunohistochemical analyses of retinal and optic nerve tissue at various time points in experimental autoimmune encephalomyelitis (EAE).Inner retinal layer (IRL) thickness was m
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Creators (Authors)
- Manogaran, Praveena
- Samardzija, Marijana
- Schad, Anaïs Nura
- Wicki, Carla Andrea
- Walker-Egger, Christine
- Rudin, Markus
- Grimm, Christian
- Schippling, Sven
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Citations
Manogaran, P., Samardzija, M., Schad, A. N., Wicki, C. A., Walker-Egger, C., Rudin, M., Grimm, C., & Schippling, S. (2019). Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis. Acta Neuropathologica Communications, 7(1), 116. https://doi.org/10.1186/s40478-019-0768-5
