Publication: cART Restores Transient Responsiveness to IFN Type 1 in HIV-Infected Humanized Mice
cART Restores Transient Responsiveness to IFN Type 1 in HIV-Infected Humanized Mice
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Gruenbach, M., Muller, C. K. S., Schlaepfer, E., Baroncini, L., Russenberger, D., Kadzioch, N. P., Escher, B., Schlapschy, M., Skerra, A., Bredl, S., & Speck, R. F. (2022). cART Restores Transient Responsiveness to IFN Type 1 in HIV-Infected Humanized Mice. Journal of Virology, 96(21), e0082722. https://doi.org/10.1128/jvi.00827-22
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The lack of a human immunodeficiency virus (HIV) cure has heightened interest in immunotherapy. As such, type I interferons (IFNs), in particular, IFN alpha (IFN-α), have gained renewed attention. However, HIV pathogenesis is driven by sustained IFN-mediated immune activation, and the use of IFNs is rather controversial. The following questions therein remain: (i) which IFN-α subtype to use, (ii) at which regimen, and (iii) at what time point in HIV infection it might be beneficial. Here, we used IFN-α14 modified by PASylation for its
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- Gruenbach, Maarja
- Muller, Christina K S
- Schlaepfer, Erika
- Baroncini, Luca
- Russenberger, Doris
- Kadzioch, Nicole P
- Escher, Benjamin
- Schlapschy, Martin
- Skerra, Arne
- Bredl, Simon
- Speck, Roberto F
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Gruenbach, M., Muller, C. K. S., Schlaepfer, E., Baroncini, L., Russenberger, D., Kadzioch, N. P., Escher, B., Schlapschy, M., Skerra, A., Bredl, S., & Speck, R. F. (2022). cART Restores Transient Responsiveness to IFN Type 1 in HIV-Infected Humanized Mice. Journal of Virology, 96(21), e0082722. https://doi.org/10.1128/jvi.00827-22