Publication: (99m) Tc radiolabeling and biological evaluation¨ of nanoparticles functionalized with a versatile coating ligand
(99m) Tc radiolabeling and biological evaluation¨ of nanoparticles functionalized with a versatile coating ligand
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Felber, M., Bauwens, M., Mateos, J. M., Imstepf, S., Mottaghy, F. M., & Alberto, R. (2015). (99m) Tc radiolabeling and biological evaluation¨ of nanoparticles functionalized with a versatile coating ligand. Chemistry, 21, 6090–6099. https://doi.org/10.1002/chem.201405704
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Radiolabeling allows noninvasive imaging by single photon emission computed tomography (SPECT) or positron emission tomography (PET) for assessing the biodistribution of nanostructures. Herein, the synthesis of a new coating ligand for gold nanoparticles (AuNPs) and quantum dots (QDs) is reported. This ligand is multifunctional; it combines the metal chelate with conjugating functions to biological vectors. The concept allows the coupling of any targeting function to the chelator; an example for the prostate specific membrane antigen
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- Felber, Michael
- Bauwens, Matthias
- Imstepf, Sebastian
- Mottaghy, Felix M
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Felber, M., Bauwens, M., Mateos, J. M., Imstepf, S., Mottaghy, F. M., & Alberto, R. (2015). (99m) Tc radiolabeling and biological evaluation¨ of nanoparticles functionalized with a versatile coating ligand. Chemistry, 21, 6090–6099. https://doi.org/10.1002/chem.201405704