Publication: Systematic identification of structure-specific protein–protein interactions
Systematic identification of structure-specific protein–protein interactions
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Holfeld, A., Schuster, D., Sesterhenn, F., Stalder, P., Haenseler, W., Barrio-Hernandez, I., Ghosh, D., Vowles, J., Cowley, S. A., Nagel, L., Khanppnavar, B., Beltrao, P., Korkhov, V. M., Riek, R., de Souza, N., & Picotti, P. (2023). Systematic identification of structure-specific protein–protein interactions (No. 522707; ArXiv.Org). https://doi.org/10.1101/2023.02.01.522707
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Abstract
Protein–protein interactions (PPIs) mediate numerous essential functions and regulatory events in living organisms. The physical interactome of a protein can be abnormally altered in response to external and internal cues, thus modulating cell physiology and contributing to human disease. In particular, neurodegenerative diseases due to the accumulation of aberrantly folded and aggregated proteins may lead to alterations in protein interactomes. Identifying changes in the interactomes of normal and disease states of proteins could hel
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Holfeld, A., Schuster, D., Sesterhenn, F., Stalder, P., Haenseler, W., Barrio-Hernandez, I., Ghosh, D., Vowles, J., Cowley, S. A., Nagel, L., Khanppnavar, B., Beltrao, P., Korkhov, V. M., Riek, R., de Souza, N., & Picotti, P. (2023). Systematic identification of structure-specific protein–protein interactions (No. 522707; ArXiv.Org). https://doi.org/10.1101/2023.02.01.522707
